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IXIARO

The U.S. Food and Drug Administration’s Center for Biologics Evaluation and Research suspended the license for IXCHIQ® on August 22, 2025. IXCHIQ® may not be distributed or administered in the United States until further notice.

Important Safety Information Prescribing Information For Healthcare Professionals
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You've been dreaming of a trip to Asia or the Western Pacific

A simple mosquito bite could ruin more than just your memories

What is Japanese encephalitis (JE)?

JE is a potentially fatal disease caused by the JE virus, which is spread by mosquitoes.

JE virus is the main cause of viral encephalitis in many Asian countries. There is no cure for JE. Treatment is focused on relieving symptoms.
Photo of a mosquito.

Around the world, there are about

68,000

cases of JE each year.

Up to

30%

of people who develop JE die.

With JE, survival is not synonymous with recovery

Only
19%
of people fully recover from JE.
Up to
50%
of people who develop JE are left with permanent brain damage and long-term disabilities.

What are the symptoms of JE? 

  • Most people infected with JE do not have symptoms or develop only mild symptoms.  
  • In people who develop severe disease, JE usually starts as a flu-like illness, with fever, chills, tiredness, headache, nausea, and vomiting.  
  • Confusion and agitation also occur in the early stage. 
  • Some people infected with JE may experience seizures and coma. 

JE can have heartbreaking consequences.

Hear how JE has affected the lives of people and their families.

Chelsea’s story

Chelsea details the long-lasting impact JE has had on her life after contracting the virus in Thailand.

John’s story

John’s parents discuss the life-changing effects of JE and the impact the disease has had on their son, John, now left with quadriplegia.

Sophie’s story

Sophie’s father shares the devastating consequences of JE, as his daughter remains paralyzed from the waist up after being infected with the virus.

The long-term effects of JE can be a significant burden for people, their families, and their community

A young couple takes a selfie in South Asia, with ornate buildings visible in the background.
A young couple takes a selfie in South Asia, with ornate buildings visible in the background.

JE risk areas

If you are traveling to any of these 25 Asia-Pacific countries, including Australia, you may be infected with JE.

  • Australia
  • Bangladesh
  • Bhutan
  • Brunei Darussalam
  • Burma (Myanmar)
  • Cambodia
  • China
  • India
  • Indonesia
  • Japan
  • Lao People’s Democratic Republic
  • Malaysia
  • Nepal
  • North Korea
  • Malaysia
  • Nepal
  • North Korea
  • Pakistan
  • Papua New Guinea
  • Philippines
  • Russia
  • Singapore
  • South Korea
  • Sri Lanka
  • Taiwan
  • Thailand
  • Timor-Leste
  • Vietnam
  • Sri Lanka
  • Taiwan
  • Thailand
  • Timor-Leste
  • Vietnam

Risk areas as of June 2024.

Ask your healthcare professional about peak JE seasons

Does your travel itinerary affect your risk?

Any of these factors may increase the risk of infection with JE:

  • Longer periods of travel
  • Traveling during the JE virus transmission season
  • Spending time in rural areas
    • JE also exists in urban areas
  • Participating in a lot of outdoor activities
  • Staying in accommodations without air conditioning, screens, or bed nets

How can you protect yourself against JE?

Vaccinate before traveling to help prevent JE.

Decorative illustration of a syringe with vaccine

Take extra steps to avoid mosquito bites, such as using insect repellent and wearing long-sleeves.

Decorative illustration of a can of bug repellant

Protect yourself like a local before you travel. Vaccination is recommended for locals in JE risk areas

The Centers for Disease Control and Prevention (CDC) recommends travelers discuss the need for vaccination with their healthcare professional.

JE vaccination is recommended for the following:
Travelers moving to a JE risk-area to live
Longer-term travelers (e.g., 1 month or longer)
Frequent travelers to JE 
risk-areas

JE vaccination should also be considered for the following:

  • Travelers who are uncertain of specific travel duration, destinations, or activities
  • Shorter-term travelers (e.g., less than 1 month) with an increased risk for JE based on:

Planned travel
duration

Season

icon_location_large

Location

Outdoor
activities

Accommodations

(e.g., no air conditioning, screens, or bed nets)

Planned travel
duration

Season

icon_location_large

Location

Outdoor
activities

Accommodations
(e.g., no air conditioning, screens, or bed nets)

The risk of JE starts at day 1. Discuss vaccination with your healthcare professional

What is IXIARO?

IXIARO is a vaccine for use in individuals 2 months of age and older to help protect against JE.

Photo of a mosquito.

IXIARO is the only approved JE vaccine available in the US, and is supported by over 14 years of experience

Does IXIARO protect against JE?

IXIARO was shown to offer protection against JE virus in children (2 months to 18 years old) and adults (18 years and older) in clinical trials. 

What are the possible side effects of IXIARO?

Illustration indicating that this section is applicable to children under 12 years of age.

Children younger than 12 years old: 

The most common side effects include:

  • Fever
  • Irritability
  • Diarrhea
  • Vomiting
  • Loss of appetite
  • Injection site pain
  • Injection site redness
Illustration indicating this section is applicable to adolescents 12 years and older, and adults.

Adolescents 12 years and older and adults:

The most common side effects include:

  • Headache
  • Muscle pain
  • Injection site reactions
    (e.g., pain, swelling, tenderness, redness)

Nausea, skin rash, fatigue, flu-like illness, fever, irritability, and loss of appetite may also occur.

Talk to your healthcare professional for more information about IXIARO 

Photo of a man seated on a wooden fence gazing at mountainous terrain.
Photo of a man seated on a wooden fence gazing at mountainous terrain.

IXIARO is a 2-dose vaccine with a flexible schedule

28-day schedule
Help protect all travelers aged 2 months and older with the 28-day schedule.1

28-day schedule

This schedule can help protect travelers aged 2 months and older.

28-day schedule
Help protect all travelers aged 2 months and older with the 28-day schedule.1

7-day rapid schedule

This schedule can help protect last-minute travelers aged 18-65. 

28-day schedule

This schedule can help protect travelers aged 2 months and older.

Illustration depicting a 28 day IXIARO vaccine administration schedule, with 28 days between doses. The second dose is administered a minimum of 7 days prior to travel.

28-day schedule

Help protect all travelers aged 2 months and older with the 28-day schedule.1

7-day rapid schedule

This schedule can help protect last-minute travelers aged 18-65.

Illustration depicting a 7 day IXIARO vaccine administration schedule, with 7 days between doses. The second dose is administered a minimum of 7 days prior to travel.

For both schedule options, the second dose should be given at least 1 week before traveling to a JE risk area.

For both schedule options, the second dose should be given at least 1 week before traveling to a JE risk area.

Do I need a booster dose of IXIARO? 

If it has been 11 months or more since your second dose of IXIARO, you should consult your healthcare professional on the need for a booster dose prior to potential re-exposure to JE virus.

It is important to get both doses. Protection is not reliable until 1 week after you receive the second dose of IXIARO

Learn more

Find IXIARO

Locate a clinic near you and book a travel health consult today.

What is IXIARO used for?

  • IXIARO is a vaccine for use in individuals 2 months of age and older to help protect against Japanese encephalitis (JE). You cannot get the disease from IXIARO.
  • You will need 2 doses of the vaccine.
  • You should consult your health care provider on the need for a booster dose of IXIARO
  • You should still protect yourself from mosquito bites even if you have had the IXIARO vaccine.
  • IXIARO may not fully protect everyone who gets the vaccine.
  • IXIARO does not protect against encephalitis caused by other viruses/pathogens.
  • IXIARO does not protect against other diseases transmitted by mosquitoes.

Important Safety Information

You should not get IXIARO if you:

  • are allergic to any of the ingredients in the vaccine. A list of ingredients can be found at the end of this leaflet.
  • had an allergic reaction after getting a dose of the vaccine or any other JEV vaccine.

IXIARO is not approved for use in infants below the age of 2 months.

What Warnings should I know about IXIARO?

  • IXIARO can cause allergic reactions. Tell your health care provider immediately if you experience difficulty breathing, hoarseness or wheezing, hives, or dizziness, weakness, or fast heartbeat.
  • Fainting can occur with administration of IXIARO.
  • Vaccination with IXIARO may not protect all who receive the vaccine.

What should I tell my health care provider?

It is very important to tell your health care provider if you:

  • have had an allergic reaction to a previous dose of IXIARO or any other JEV vaccine.
  • have a bleeding disorder or a reduction in blood platelets, which increases risk of bleeding
  • or bruising (thrombocytopenia) and cannot receive injections in the arm.
  • have a weakened immune system, for example, due to a genetic defect or HIV infection.
  • are or may be pregnant, or are breast feeding. IXIARO has not been studied in pregnant women or nursing mothers.
  • currently have any illness with a fever of more than 100 F (37.8 C).
  • take any medicines, even those you can buy over the counter.

What are the side effects of IXIARO?

The most common side effects in adolescents >12 years of age and adults are headache, muscle pain and injection site reactions (e.g. pain, swelling, tenderness, redness). Nausea, skin rash, fatigue, flu-like illness, fever, irritability and loss of appetite may also occur.

The most common side effects in children below the age of 12 years are fever, irritability, diarrhea, vomiting, loss of appetite, injection site pain and injection site redness.

Contact your health care provider right away if you get any symptoms after receiving IXIARO that concern you.
Tell your health care provider if you have any of the following problems because these may be signs of an allergic reaction:

  • difficulty breathing
  • hoarseness or wheezing
  • hives
  • dizziness, weakness or fast heart beat

You are encouraged to report suspected adverse reactions to Valneva at 1-844-349-4276 or VAERS at 1-800-822-7967 or http://vaers.hhs.gov.

Please click here for full Prescribing Information for IXIARO.

What is IXIARO used for?

  • IXIARO is a vaccine for use in individuals 2 months of age and older to help protect against Japanese encephalitis (JE). You cannot get the disease from IXIARO.
  • You will need 2 doses of the vaccine.
  • You should consult your health care provider on the need for a booster dose of IXIARO
  • You should still protect yourself from mosquito bites even if you have had the IXIARO vaccine.
  • IXIARO may not fully protect everyone who gets the vaccine.
  • IXIARO does not protect against encephalitis caused by other viruses/pathogens.
  • IXIARO does not protect against other diseases transmitted by mosquitoes.

You should not get IXIARO if you:

  • are allergic to any of the ingredients in the vaccine. A list of ingredients can be found at the end of this leaflet.
  • had an allergic reaction after getting a dose of the vaccine or any other JEV vaccine.

IXIARO is not approved for use in infants below the age of 2 months.

What Warnings should I know about IXIARO?

  • IXIARO can cause allergic reactions. Tell your health care provider immediately if you experience difficulty breathing, hoarseness or wheezing, hives, or dizziness, weakness, or fast heartbeat.
  • Fainting can occur with administration of IXIARO.
  • Vaccination with IXIARO may not protect all who receive the vaccine.

What should I tell my health care provider?

It is very important to tell your health care provider if you:

  • have had an allergic reaction to a previous dose of IXIARO or any other JEV vaccine.
  • have a bleeding disorder or a reduction in blood platelets, which increases risk of bleeding
  • or bruising (thrombocytopenia) and cannot receive injections in the arm.
  • have a weakened immune system, for example, due to a genetic defect or HIV infection.
  • are or may be pregnant, or are breast feeding. IXIARO has not been studied in pregnant women or nursing mothers.
  • currently have any illness with a fever of more than 100 F (37.8 C).
  • take any medicines, even those you can buy over the counter.

What are the side effects of IXIARO?

The most common side effects in adolescents >12 years of age and adults are headache, muscle pain and injection site reactions (e.g. pain, swelling, tenderness, redness). Nausea, skin rash, fatigue, flu-like illness, fever, irritability and loss of appetite may also occur.

The most common side effects in children below the age of 12 years are fever, irritability, diarrhea, vomiting, loss of appetite, injection site pain and injection site redness.

Contact your health care provider right away if you get any symptoms after receiving IXIARO that concern you.
Tell your health care provider if you have any of the following problems because these may be signs of an allergic reaction:

  • difficulty breathing
  • hoarseness or wheezing
  • hives
  • dizziness, weakness or fast heart beat

You are encouraged to report suspected adverse reactions to Valneva at 1-844-349-4276 or VAERS at 1-800-822-7967 or http://vaers.hhs.gov.

Please click here for full Prescribing Information for IXIARO.

What is IXIARO used for?

  • IXIARO is a vaccine for use in individuals 2 months of age and older to help protect against Japanese encephalitis (JE). You cannot get the disease from IXIARO.
  • You will need 2 doses of the vaccine.
  • You should consult your health care provider on the need for a booster dose of IXIARO
  • You should still protect yourself from mosquito bites even if you have had the IXIARO vaccine.
  • IXIARO may not fully protect everyone who gets the vaccine.
  • IXIARO does not protect against encephalitis caused by other viruses/pathogens.
  • IXIARO does not protect against other diseases transmitted by mosquitoes.

Important Safety Information

You should not get IXIARO if you:

  • are allergic to any of the ingredients in the vaccine. A list of ingredients can be found at the end of this leaflet.
  • had an allergic reaction after getting a dose of the vaccine or any other JEV vaccine.

IXIARO is not approved for use in infants below the age of 2 months.

What Warnings should I know about IXIARO?

  • IXIARO can cause allergic reactions. Tell your health care provider immediately if you experience difficulty breathing, hoarseness or wheezing, hives, or dizziness, weakness, or fast heartbeat.
  • Fainting can occur with administration of IXIARO.
  • Vaccination with IXIARO may not protect all who receive the vaccine.

What should I tell my health care provider?

It is very important to tell your health care provider if you:

  • have had an allergic reaction to a previous dose of IXIARO or any other JEV vaccine.
  • have a bleeding disorder or a reduction in blood platelets, which increases risk of bleeding
  • or bruising (thrombocytopenia) and cannot receive injections in the arm.
  • have a weakened immune system, for example, due to a genetic defect or HIV infection.
  • are or may be pregnant, or are breast feeding. IXIARO has not been studied in pregnant women or nursing mothers.
  • currently have any illness with a fever of more than 100 F (37.8 C).
  • take any medicines, even those you can buy over the counter.

What are the side effects of IXIARO?

The most common side effects in adolescents >12 years of age and adults are headache, muscle pain and injection site reactions (e.g. pain, swelling, tenderness, redness). Nausea, skin rash, fatigue, flu-like illness, fever, irritability and loss of appetite may also occur.

The most common side effects in children below the age of 12 years are fever, irritability, diarrhea, vomiting, loss of appetite, injection site pain and injection site redness.

Contact your health care provider right away if you get any symptoms after receiving IXIARO that concern you.
Tell your health care provider if you have any of the following problems because these may be signs of an allergic reaction:

  • difficulty breathing
  • hoarseness or wheezing
  • hives
  • dizziness, weakness or fast heart beat

You are encouraged to report suspected adverse reactions to Valneva at 1-844-349-4276 or VAERS at 1-800-822-7967 or http://vaers.hhs.gov.

Please click here for full Prescribing Information for IXIARO.

What is IXIARO used for?

  • IXIARO is a vaccine for use in individuals 2 months of age and older to help protect against Japanese encephalitis (JE). You cannot get the disease from IXIARO.
  • You will need 2 doses of the vaccine.
  • You should consult your health care provider on the need for a booster dose of IXIARO
  • You should still protect yourself from mosquito bites even if you have had the IXIARO vaccine.
  • IXIARO may not fully protect everyone who gets the vaccine.
  • IXIARO does not protect against encephalitis caused by other viruses/pathogens.
  • IXIARO does not protect against other diseases transmitted by mosquitoes.

You should not get IXIARO if you:

  • are allergic to any of the ingredients in the vaccine. A list of ingredients can be found at the end of this leaflet.
  • had an allergic reaction after getting a dose of the vaccine or any other JEV vaccine.

IXIARO is not approved for use in infants below the age of 2 months.

What Warnings should I know about IXIARO?

  • IXIARO can cause allergic reactions. Tell your health care provider immediately if you experience difficulty breathing, hoarseness or wheezing, hives, or dizziness, weakness, or fast heartbeat.
  • Fainting can occur with administration of IXIARO.
  • Vaccination with IXIARO may not protect all who receive the vaccine.

What should I tell my health care provider?

It is very important to tell your health care provider if you:

  • have had an allergic reaction to a previous dose of IXIARO or any other JEV vaccine.
  • have a bleeding disorder or a reduction in blood platelets, which increases risk of bleeding
  • or bruising (thrombocytopenia) and cannot receive injections in the arm.
  • have a weakened immune system, for example, due to a genetic defect or HIV infection.
  • are or may be pregnant, or are breast feeding. IXIARO has not been studied in pregnant women or nursing mothers.
  • currently have any illness with a fever of more than 100 F (37.8 C).
  • take any medicines, even those you can buy over the counter.

What are the side effects of IXIARO?

The most common side effects in adolescents >12 years of age and adults are headache, muscle pain and injection site reactions (e.g. pain, swelling, tenderness, redness). Nausea, skin rash, fatigue, flu-like illness, fever, irritability and loss of appetite may also occur.

The most common side effects in children below the age of 12 years are fever, irritability, diarrhea, vomiting, loss of appetite, injection site pain and injection site redness.

Contact your health care provider right away if you get any symptoms after receiving IXIARO that concern you.
Tell your health care provider if you have any of the following problems because these may be signs of an allergic reaction:

  • difficulty breathing
  • hoarseness or wheezing
  • hives
  • dizziness, weakness or fast heart beat

You are encouraged to report suspected adverse reactions to Valneva at 1-844-349-4276 or VAERS at 1-800-822-7967 or http://vaers.hhs.gov.

Please click here for full Prescribing Information for IXIARO.

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